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Hydroxyzine 2HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxyzine 2HCl图片
CAS NO:2192-20-3
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)447.83
FormulaC21H27ClN2O2.2HCl
CAS No.2192-20-3 (2HCl);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 90 mg/mL (201 mM)
Water: 90 mg/mL (201 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)Saline: 30 mg/mL
SynonymsHydroxyzine dihydrochloride; NSC 169188; U.C.B 4492; Hydroxyzine hydrochloride; NSC-169188; NSC169188; trade names: Arcanax; Neurolax; Orgatrax; Pamoate, Hydroxyzine; Vistaril;
实验参考方法
In Vitro

In vitro activity: Hydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE). Hydroxyzine (500 μM) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 μg/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen.


Kinase Assay: Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist. Target: Histamine H1-Receptor Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.


Cell Assay: Hydroxyzine dihydrochloride (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE). Hydroxyzine dihydrochloride (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine dihydrochloride significantly reduces the efflux and approximately 2.4 g/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen. H

In VivoHydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
Animal modelSprague-Dawley rats
Formulation & DosageDissolved in saline; 50 mg/kg; i.v. injection
ReferencesInt J Immunopharmacol. 1998 Oct;20(10):553-63; Anticancer Drugs. 2001 Mar;12(3):267-73.