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Cyclizine 2HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyclizine 2HCl图片
CAS NO:5897-18-7
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)339.3
FormulaC18H22N2.2HCl
CAS No.5897-18-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 7 mg/mL (20.6 mM)
Water: 68 mg/mL (200.41 mM)
Ethanol: <1 mg/mL
SMILESCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl.Cl
SynonymsCyclizine 2HCl; Marezine; Ciclizina; Nautazine; Valoid; Neo-devomit
实验参考方法
In Vitro

In vitro activity: Cyclizine is a histamine H1 receptor antagonist of the piperazine class. It possesses anticholinergic and antiemetic properties. The mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated. Cyclizine increases lower oesophageal sphincter tone and reduces the sensitivity of the labyrinthine apparatus. It may inhibit the part of the midbrain known collectively as the emetic centre.

In VivoCyclizine is metabolised to its N-demethylated derivative, norcyclizine, which has little antihistaminic (H1) activity compared to Cyclizine. Following oral administration effects develop within 30 minutes, are maximal within 1-2 hours and last, for cyclizine, for 4-6 hours. In healthy adult volunteers the administration of a single oral dose of 50 mg cyclizine resulted in a peak plasma concentration of approximately 70 ng/mL occurring at about two hours after drug administration. The plasma elimination half-life is approximately 20 hours.
Animal model
Formulation & Dosage
ReferencesJ Anal Toxicol. 2014 Mar;38(2):110-2.