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Netupitant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Netupitant图片
CAS NO:290297-26-6
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍

Netupitant (formerly CID-6451149; AGE-94200; Ro 67-3189) is an orally bioavailable neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. It inhibits NK1 with a Ki of 0.95 nM. The combination drug netupitant/palonosetron was approved by FDA in 2018 for prevention of acute and delayed chemotherapy-induced nausea and vomiting, including highly emetogenic chemotherapy such as with cisplatin. Netupitant competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).

纯度:≥98%

CAS:290297-26-6