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SL-327
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SL-327图片
CAS NO:305350-87-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
SL 327, SL327
产品介绍

生物活性

SL-327是MEK1和MEK2的选择性抑制剂(IC50值分别为0.18和0.22μM);在体外阻断海马LTP。全身性给药后,体内的脑渗透剂会阻止大鼠的恐惧条件和学习,并在小鼠中产生神经保护作用。

Targets

TargetValue
MEK1IC50: 0.18μM
MEK2IC50: 0.22μM
AP-1IC50: 2.03μM
PKCIC50: >10μM
MKK3/p38MAPKIC50: 21μM
ERK1IC50: >50μM
MKK4IC50: >100μM
JNKIC50: >100μM

化学数据

目录号A14137
作用机制Inhibitor (抑制剂)
M. Wt335.4
FormulaC16H12F3N3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.305350-87-2
SynonymsSL 327, SL327
SMILESC1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

溶解度

In vitro (25°C)DMSO66 mg/mL (196.81 mM)
WaterInsoluble
Ethanol7 mg/mL (20.87 mM)
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM29.82 mL149.08 mL298.15 mL
0.5 mM5.96 mL29.82 mL59.63 mL
1 mM2.98 mL14.91 mL29.82 mL
5 mM0.6 mL2.98 mL5.96 mL

*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.