Description: Levobetaxolol (also known as AL 1577A; Betaxon and AL-1577A), a potent beta-adrenergic receptor inhibitor /beta blocker, is the S-isomer of betaxolol which exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. It is used to lower the pressure in the eye in treating conditions such as glaucoma. Levobetaxolol potently antagonizes functional activities at cloned human β1 and β2 receptors, respectively. Levobetaxolol (Ki = 16.4 nM) is more potent than dextrobetaxolol (Ki = 2.97 μM) at inhibiting isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells.

References: J Ocul Pharmacol Ther. 2001 Aug;17(4):305-17; Exp Eye Res. 2002 Apr;74(4):445-53.

Related CAS#: 116209-55-3 (HCl); 93221-48-8 (free base)

纯度：≥98%

CAS：93221-48-8