SBI-0206965 HCl is a cell permeable and selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, it is about 7-fold selectivity over ULK2. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.

纯度：≥98%