生物活性
AZD8186是磷酸肌醇-3激酶(PI3K)β亚型的抑制剂，具有潜在的抗肿瘤活性。
化学数据
| 目录号 | A14164 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 457.47 |
| Formula | C24H25F2N3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1296270-45-5 |
| Synonyms | AZD-8186, AZD 8186 |
| SMILES | O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.86 mL | 109.3 mL | 218.59 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.72 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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