| CAS NO: | 21535-47-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 300.83 |
|---|---|
| Formula | C18H20N2·HCl |
| CAS No. | 21535-47-7 (HCl salt); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 60 mg/mL (199.4 mM) |
| Water: 30 mg/mL (99.7 mM) | |
| Ethanol: 21 mg/mL (69.8 mM) | |
| Other info | Chemical Name: 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine InChi Key: UEQUQVLFIPOEMF-UHFFFAOYSA-N InChi Code: InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 SMILES Code: CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42 |
| Synonyms | ORG GB-94 HCl; Mianserin, Depnon, Lerivon, Lumin,Lantanon, ORG GB-94 HCl; ORG GB 94 HCl; Norval, Tolvon |
| In Vitro | In vitro activity: Mianserin (2 mg/kg s.c.) causes a modest increase of DOPAC levels up to about 30% above base-line, which is statistically significant when compared to saline. Mianserin increases extracellular norepinephnne, but a comparison with desipramine and idazoxan showed that both NE reuptake inhibition and alpha-2 autoreceptor blockade contributed to the mianserin-induced increase in extracellular norepinephnne. Mianserin and eltoprazine displays opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while eltoprazine shows anxiogenic-like ones. Mianserin treatment induces a decrease in the number of these sites, while eltoprazine treatment results in an increase. |
|---|---|
| In Vivo | Mianserin, which has a small or no effect in noradrenaline (NA) reuptake but may enhance release by blocking presynaptic inhibition mediated by alpha 2-adrenoceptors, induced regeneration of catecholamine fibers in the rat cerebral cortex. Mianserin attenuates the effects of both m-CPP and SKF 38393 in neonatal 6-OHDA-lesioned rats, suggesting that DA agonist effects are mediated by 5-HT neurochemical systems. Mianserin (10 mg/kg, SC) dose-dependently increases up to about 6 times extracellular dopamine in the medial prefrontal cortex of the rat. Mianserin also dose-dependently increases extracellular noradrenaline in the prefrontal cortex. |
| Animal model | Rats |
| Formulation & Dosage | 10 mg/kg, SC |
| References | J Pharmacol Exp Ther. 1996 May;277(2):852-60; Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31; Neuroreport. 1991 Sep;2(9):525-8. |
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