您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Bazedoxifene
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bazedoxifene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bazedoxifene图片
CAS NO:198481-32-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

Description: Bazedoxifene (also known as TSE-424; WAY140424), a novel third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. Bazedoxifene does not stimulate ERα mediated transcriptional activity and acts as an antagonist to estradiol in cultured breast cancer (bMCF-7) cells. Similar results are seen in other cell lines including CHO (ovarian), HepG2 (hepatic) or GTI-7 (neuronal) with bazedoxifene having no ERα agonist activity and acting as an antagonist to estradiol action.

References: Clin Interv Aging. 2007 Sep; 2(3): 299–303; Endocrinology. 2005 Sep;146(9):3999-4008.

Related CAS #: 198480-56-7 (HCl); 198481-32-2 (free base); 198481-33-3 (acetate)

纯度:≥98%

CAS:198481-32-2