CAS NO: | 53-59-8 |
规格: | 98% |
分子量: | 743.4 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
500mg | 电议 |
1g | 电议 |
NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate.
CAS:53-59-8
分子式:C21H28N7O17P3
分子量:743.4
纯度:98%
存储:Store at -20°C
Background:
NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate(NADPH.Item No.ajce52358). It serves as a cofactor in various biological reactions.[1],[2] In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.[2],[3] For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation.[4] NADP+ is biosynthesized from NAD+ (Item No.ajci18674) by NAD kinase, with ATP as the phosphoryl donor[5].
Reference:
[1]. Jackson, J.B. A review of the binding-change mechanism for proton-translocating transhydrogenase. Biochimica et Biophysica Acta 1817(10), 1839-1846 (2012).
[2]. Nakamura, M., Bhatnagar, A., and Sadoshima, J. Overview of pyridine nucleotides review series. Circ. Res. 111(5), 604-610 (2012).
[3]. Ziegler, M. A vital link between energy and signal transduction: Regulatory functions of NAD(P). FEBS Journal 272(18), 4561-4564 (2014).
[4]. Kilfoil, P.J., Tipparaju, S.M., Barski, O.A., et al. Regulation of ion channels by pyridine nucleotides. Circ. Res. 112(4), 721-741 (2013).
[5]. Shi, F., Li, Y., Li, Y., et al. Molecular properties, functions, and potential applications of NAD kinases. Acta Biochim. Biophys. Sin. (Shanghai) 41(5), 352-361 (2009).