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Diphenhydramine HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diphenhydramine HCl图片
CAS NO:147-24-0
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)291.82
FormulaC17H21NO.HCl
CAS No.147-24-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 58 mg/mL (198.8 mM)
Water: 58 mg/mL (198.8 mM)
Ethanol: 58 mg/mL (198.8 mM)
Other info

Chemical Name: 2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride

InChi Key: PCHPORCSPXIHLZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

SMILES Code: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Synonyms

PM 255; Diphenhydramine; Dabylen; PM255; PM-255; Debendrin; Difenhydramine.

实验参考方法
In Vitro

In vitro activity: Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents. Diphenhydramine causes a shift of the steady-state inactivation curve for both types of sodium currents in the hyperpolarizing direction. Diphenhydramine produces a profound use-dependent block when the cells are repeatedly stimulated with high-frequency depolarizing pulses. Diphenhydramine induces apoptosis in a dose- and time-dependent manner in both CCRF-CEM and Jurkat cell lines, whereas Cimetidine fails to induce significant effects at similar concentrations. Diphenhydramine-induced apoptosis is evaluated in terms of morphology, flow cytometry, and the release of cytochrome c to the cytosol. Diphenhydramine inhibits cell proliferation without inducing apoptosis in human peripheral blood mononuclear cells. Diphenhydramine (500 nM) significantly reduces the baseline firing of the periaqueductal gray neurons without a significant effect on the frequency of postsynaptic potentials. Diphenhydramine at high concentration inhibits periaqueductal gray neurons, but at low concentrations it has no effect on the baseline-firing rate and it blocks the response to neurotensin and tomedial preoptic nucleus stimulation.

In Vivo
Animal model
Formulation & Dosage
References

Brain Res. 2000 Oct 27;881(2):190-8; Oncol Res. 2004;14(7-8):363-72.