CAS NO: | 147-24-0 |
规格: | ≥98% |
包装 | 价格(元) |
1g | 电议 |
2g | 电议 |
5g | 电议 |
10g | 电议 |
25g | 电议 |
Molecular Weight (MW) | 291.82 |
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Formula | C17H21NO.HCl |
CAS No. | 147-24-0 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 58 mg/mL (198.8 mM) |
Water: 58 mg/mL (198.8 mM) | |
Ethanol: 58 mg/mL (198.8 mM) | |
Other info | Chemical Name: 2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride InChi Key: PCHPORCSPXIHLZ-UHFFFAOYSA-N InChi Code: InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H SMILES Code: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl |
Synonyms | PM 255; Diphenhydramine; Dabylen; PM255; PM-255; Debendrin; Difenhydramine. |
In Vitro | In vitro activity: Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents. Diphenhydramine causes a shift of the steady-state inactivation curve for both types of sodium currents in the hyperpolarizing direction. Diphenhydramine produces a profound use-dependent block when the cells are repeatedly stimulated with high-frequency depolarizing pulses. Diphenhydramine induces apoptosis in a dose- and time-dependent manner in both CCRF-CEM and Jurkat cell lines, whereas Cimetidine fails to induce significant effects at similar concentrations. Diphenhydramine-induced apoptosis is evaluated in terms of morphology, flow cytometry, and the release of cytochrome c to the cytosol. Diphenhydramine inhibits cell proliferation without inducing apoptosis in human peripheral blood mononuclear cells. Diphenhydramine (500 nM) significantly reduces the baseline firing of the periaqueductal gray neurons without a significant effect on the frequency of postsynaptic potentials. Diphenhydramine at high concentration inhibits periaqueductal gray neurons, but at low concentrations it has no effect on the baseline-firing rate and it blocks the response to neurotensin and tomedial preoptic nucleus stimulation. |
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In Vivo | |
Animal model | |
Formulation & Dosage | |
References | Brain Res. 2000 Oct 27;881(2):190-8; Oncol Res. 2004;14(7-8):363-72. |