Restorer of wild-type p53 conformation/cellular function
CAS:72835-26-8
分子式:C8H9NO4
分子量:183.16
纯度:98%
存储:Store at -20°C
Background:
Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent mannerin vitro(IC50= 10μM).