您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CA-4948
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CA-4948
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CA-4948图片
CAS NO:1801343-74-7
规格:98%
分子量:417.42
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CA-4948是一种有选择性且有效的IRAK4抑制剂。
CAS:1801343-74-7
分子式:C21H19N7O3
分子量:417.42
纯度:98%
存储:Store at -20°C

Background:

CA-4948 is a selective and potent IRAK4 inhibitor.



CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].


[1]. Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. AACR Annual Meeting 2017; April 1-5, 2017;