(-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂,具有镇痛作用。
CAS:2244989-34-0
分子式:C24H26F2N6O
分子量:452.5
纯度:98%
存储:Store at -20°C
Background:
(-)-(S)-B-973B is a potent allosteric agonism and positive allosteric modulation (ago-PAM) for α7 nAChR, with antinociceptive activity[1].
[1]. Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148.