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DC41-SMe
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DC41-SMe图片
CAS NO:1354787-71-5
规格:98%
分子量:726.31
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
DC41-SMe 是一种 DC1 衍生物,对 Ramos、Namalwa 和 HL60/s 细胞显示细胞毒性,IC50 值为 18-25 pM。DC1,CC-1065 的简化类似物,是用于靶向治疗癌症的细胞毒性 DNA 烷基化酶的抗体偶联物。
CAS:1354787-71-5
分子式:C38H36ClN5O4S2
分子量:726.31
纯度:98%
存储:Store at -20°C

Background:

DC41-SMe is a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].




[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.