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ERK5-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ERK5-IN-1图片
CAS NO:1234479-76-5
规格:98%
分子量:459.54
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
ERK5-IN-1是一种有效的ERK5抑制剂,IC50为87±7nM。ERK5-IN-1也抑制LRRK2[G2019S],IC50为26nM。
CAS:1234479-76-5
分子式:C25H29N7O2
分子量:459.54
纯度:98%
存储:Store at -20°C

Background:

ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM.


ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM[1].



[1]. Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.