您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Angiotensin II 5-valine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Angiotensin II 5-valine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin II 5-valine图片
CAS NO:58-49-1
规格:98%
分子量:1032.15
包装与价格:
包装价格(元)
200mg电议
500mg电议
5mg电议
50mg电议
100mg电议

产品介绍
Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。
CAS:58-49-1
分子式:C49H69N13O12
分子量:1032.15
纯度:98%
存储:Store at -20°C

Background:

Angiotensin II 5-valine is an agonist of angiotensin receptor. Angiotensin receptor[1].



By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].


[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.