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AZD1390
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD1390图片
CAS NO:2089288-03-7
规格:98%
分子量:477.57
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
1g电议

产品介绍
AZD1390 is a potent and selective ATM inhibitor
CAS: 2089288-03-7
分子式:C27H32FN5O2
分子量:477.57
纯度:98%
存储:Store at -20°C

Background:

AZD1390 is a potent and selective ATM inhibitor with the ability to cross the blood-brain barrier suitable for the treatment of intracranial malignancies.AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50 = 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.


AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies.


Reference:


http://mct.aacrjournals.org/content/17/1_Supplement/A124