Dapansutrile(OLT1177)是有效,选择性和有口服活性的NLRP3炎性小体抑制剂。具有抗炎,镇痛活性。
CAS:54863-37-5
分子式:C4H7NO2S
分子量:133.17
纯度:98%
存储:Store at -20°C
Background:
Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity[1].
NLRP3 inflammasome[1]
[1]. Toldo S, et al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.