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ZM39923
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZM39923图片
CAS NO:273727-89-2
规格:98%
分子量:331.45
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ZM39923 是一种 JAK3 抑制剂, pIC50 值为 7.1;ZM39923 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性,IC50 值为 10 nM。
CAS:273727-89-2
分子式:C23H25NO
分子量:331.45
纯度:98%
存储:Store at -20°C

Background:

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. JAK3|7.1 (pIC50)|JAK1|4.4 (pIC50)|EGF-R|5.6 (pIC50)|Lck|5.0 (pIC50)|CDK4|5.0 (pIC50)|TGM2|10 nM (IC50)


ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50<5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3].



[1]. Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. [2]. Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. [3]. Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197.