CAS NO: | 1340593-59-0 |
规格: | 98% |
分子量: | 527.39 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
25mg | 电议 |
Oteseconazole (VT-1161) 是一种有效、可口服的抗真菌剂,有效结合并抑制白色念球菌的 CYP51 (Kd,<39 nm),但对人 cyp51 无明显作用。
CAS:1340593-59-0
分子式:C23H16F7N5O2
分子量:527.39
纯度:98%
存储:Store at -20°C
Background:
Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd,<39 nM), shows no obvious effect on human CYP51[1][2].
[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.