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2',3',5'-triacetyl-5-Azacytidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2',3',5'-triacetyl-5-Azacytidine图片
CAS NO:10302-78-0
规格:98%
分子量:370.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
CAS:10302-78-0
分子式:C14H18N4O8
分子量:370.3
纯度:98%
存储:Store at -20°C

Background:

2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2].


The DNA methyltransferase belongs to a family of enzymes involved in catalyzing the transfer of a methyl group to DNA. DNA methylation has been implicated in regulating gene expression in normal and malignant cells [2].


In vivo: In CD-1 mice, oral administration of TAC for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. TAC inhibited global DNA methylation in the spleen and gut. In an in vivo L1210 leukemia model, TAC exhibited antineoplastic activity [1].


参考文献:
[1] Ziemba A, Ramirez M C, Freeman B, et al.  Abstract# 3369: Development of oral demethylating agents for the treatment of myelodysplastic syndrome[J]. 2009.
[2] Brueckner B, Boy R G, Siedlecki P, et al.  Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases[J]. Cancer research, 2005, 65(14): 6305-6311.