CAS NO: | 2058264-32-5 |
规格: | 98% |
分子量: | 498.53 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of<100 nM. TBK1|100 nM (IC50)|IKKε|100 nM (IC50)
IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].
[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1.