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SL 0101-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SL 0101-1图片
CAS NO:77307-50-7
规格:98%
分子量:516.46
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍

ribosomal S6 kinase inhibitor
CAS:77307-50-7
分子式:C25H24O12
分子量:516.46
纯度:98%
存储:Store at -20°C

Background:

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

参考文献:
[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.