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CHK1-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CHK1-IN-3图片
CAS NO:2097252-39-4
规格:98%
分子量:405.46
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂,IC50 值为 0.4 nM。
CAS:2097252-39-4
分子式:C20H23N9O
分子量:405.46
纯度:98%
存储:Store at -20°C

Background:

CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM[1]. Chk1|0.4 nM (IC50)


CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM) and displays low affinity for hERG (IC50 >40 µM)[1].


CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected[1].


[1]. Tong L, et al. Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62.