ALK-IN-6 (compound 11) 是口服有效的，间变性淋巴瘤激酶 (ALK) 的抑制剂，其对野生型 ALK、ALK F1196M 和ALK F1174L 的 IC50 值分别为 71 nM、18.72 nM 和36.81 nM。
CAS：2055821-33-3
分子式：C26H29D3ClN5O3S
分子量：533.1
纯度：98%
存储：Store at -20°C

Background:

ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1]. IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].

[1]. Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1514-1517.