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Loureirin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loureirin A图片
CAS NO:119425-89-7
包装:5mg
规格:98%
市场价:1738元
分子量:286.32

产品介绍
LoureirinA是从龙血树中分离到的黄酮类物质,能够降低Akt的磷酸化,具有抗血小板聚集的作用。
CAS:119425-89-7
分子式:C17H18O4
分子量:286.32
纯度:98%
存储:Store at -20°C

Background:

Loureirin A is a flavonoid extracted from Dragon’s Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.


Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].



[1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.