您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PQR309
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PQR309
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PQR309图片
CAS NO:1225037-39-7
规格:98%
分子量:411.38
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
PQR309 is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively.
CAS:1225037-39-7
分子式:C17H20F3N7O2
分子量:411.38
纯度:98%
存储:Store at -20°C

Background:

PQR309 is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. PQR309 is an mTORC1 and mTORC2 inhibitor.


PQR309 is a highly selective pan-PI3K inhibitor with a balanced targeting of mTOR kinase. PQR309 also inhibits PI3Kα-H1047R), PI3Kα-E542K and PI3Kα-E545K with IC50s of 36 nM, 63nM and 136 nM, respectively[1].


Oral administration yields similar concentrations of PQR309 in brain and plasma samples illustrates that PQR309 readily passes the blood-brain barrier. In mice, both po and iv application routes show a rapid drop below 200 ng/mL (