ionophore
CAS：56092-82-1
分子式：C41H70O9.Ca
分子量：747.08
纯度：98%
存储：Store at -20°C

Background:

Lonomycin is a selective calcium ionophore derived from S. conglobatus that mobilizes intracellular calcium stores.[1] It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.[2],[3],[4] This compound is supplied as a calcium salt for more stable storage. It is also available as a solution in ethanol.

Reference:
[1]. Liu, W.C., Slusarchyk, D.S., Astle, G., et al. Ionomycin, a new polyether antibiotic. Journal of Antibiotics 31(9), 815-819 (1978).
[2]. Morgan, A.J., and Jacob, R. Ionomycin enhances Ca2+ influx by stimulating store-regulated. Biochemistry Journal 300, 665-672 (1994).
[3]. Yoshida, S., and Plant, S. Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xeonopus laevis. Journal of Physiology 458, 307-318 (1992).
[4]. Caraher, E.M., Parenteau, M., Gruber, H., et al. Flow cytometric analysis of intracellular IFN-γ, IL-4 and IL-10 in CD3+4+ T-cells from rat spleen. Journal of Immunological Methods 244, 29-40 (2000).