Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions
CAS：1315378-72-3
分子式：C58H79N15O16
分子量：1242.37
纯度：98%
存储：Store at -20°C

Background:

Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents. Being structurally similar to anther peptide PanxE1B, 10Panx is three amino acid shorter but exerting an inhibitory effect against pannexin1 currents in oocytes to a similar extent as PanxE1b. 10Panx is also able to block the activation of I_2nd, decrease the bradykinin-induced [Ca²⁺]_iresponse and attenuate bradykinin-induced ATP release from human fibroblasts loaded with quinacrine. However, in several studies, scrambled 10Panx has been proved to be less effective than 10Panx in its authentic form.

Reference

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