CAS NO: | 1532533-69-9 |
规格: | 98% |
分子量: | 571.55 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
2mg | 电议 |
5mg | 电议 |
Background:
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. PI3Kδ
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor’s IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].
[1]. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1.