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Umbralisib R-enantiomer
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Umbralisib R-enantiomer图片
CAS NO:1532533-69-9
规格:98%
分子量:571.55
包装与价格:
包装价格(元)
10mg电议
50mg电议
2mg电议
5mg电议

产品介绍
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) 是 PI3Kδ 抑制剂,是 TGR-1202 活性较低的对映体。
CAS:1532533-69-9
分子式:C31H24F3N5O3
分子量:571.55
纯度:98%
存储:Store at -20°C

Background:

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. PI3Kδ


Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor’s IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].



[1]. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1.