Amotosalen hydrochloride (S-59) 是一种光活化的 DNA 和 RNA 交联的补骨脂素化合物，可用于中和病原体。
CAS：161262-45-9
分子式：C17H21Cl2NO4
分子量：374.26
纯度：98%
存储：Store at -20°C

Background:

Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens[1].

When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].

[1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8.