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Rapastinel Trifluoroacetate(GLYX-13 Trifluoroacetate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rapastinel Trifluoroacetate(GLYX-13 Trifluoroacetate)图片
CAS NO:1435786-04-1
规格:98%
分子量:527.49
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
RapastinelTrifluoroacetate是一种具有甘氨酸位点部分激动剂性质的NMDA受体调节剂,目前正处于II期临床开发项目中,作为重度抑郁症的辅助治疗。
CAS:1435786-04-1
分子式:C20H32F3N5O8
分子量:527.49
纯度:98%
存储:Store at -20°C

Background:

Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder.



Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P0.05][2].


[1]. Rajagopal L, et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behav Brain Res. 2016 Feb 15;299:105-10. [2]. Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.