Tiagabine hydrochloride hydrate 是一种有效、选择性的 GABA uptake 抑制剂,为抗惊厥剂;在突触体、神经元和神经胶质中,能够抑制 [3H]GABA 的摄取,IC50 值分别为 67,446 和 182 nM。
CAS:145821-57-4
分子式:C20H28ClNO3S2
分子量:430.02
纯度:98%
存储:Store at -20°C
Background:
Tiagabine hydrochloride hydrate is a potent and selective GABA uptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].
[1]. Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.