您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Bruceine D
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bruceine D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bruceine D图片
CAS NO:21499-66-1
规格:98%
分子量:410.42
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Bruceine D 是Notch 抑制剂,具有抗癌活性,并诱导几种人癌细胞调亡。Bruceine D 是一种有效的植物性昆虫拒食剂,具有显著的系统特性和很强的抑制害虫生长的作用。
CAS:21499-66-1
分子式:C20H26O9
分子量:410.42
纯度:98%
存储:Store at -20°C

Background:

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Notch[1]


Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6?μM, respectively, at 48?h of treatment[1]. Bruceine D (0.125-1.0?μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].



[1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205.