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CK 869
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CK 869图片
CAS NO:388592-44-7
规格:98%
分子量:394.28
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
actin-related protein 2/3 (Arp2/3) complex inhibitor
CAS:388592-44-7
分子式:C17H16BrNO3S
分子量:394.28
纯度:98%
存储:Store at -20°C

Background:

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.


CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].


参考文献:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.
[2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.