Mcl1-IN-11 (Compound G) 是一种选择性的 Mcl-1 抑制剂,对 Bcl-2 的作用较弱,Ki 值分别为 0.06 和 4.2 μM。
CAS:2042211-13-0
分子式:C38H41N3O5S2
分子量:683.88
纯度:98%
存储:Store at -20°C
Background:
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively[1].
Ki: 0.06 (Mcl-1), 4.2 μM (Bcl-2)[1]
[1]. Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.