CAS NO: | 2364489-81-4 |
规格: | 98% |
分子量: | 683.01 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Background:
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1]. CDK14/Cyclin Y|39.6 nM (IC50, in NanoBRET assay)|CDK2|256 nM (IC50, in NanoBRET assay)
FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1,144±190 nM[1].
[1]. Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.