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HX 531
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HX 531图片
CAS NO:188844-34-0
规格:98%
分子量:483.56
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
RXR antagonist
CAS:188844-34-0
分子式:C29H29N3O4
分子量:483.56
纯度:98%
存储:Store at -20°C

Background:

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid -induced transactivation of RXR.[1] It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.[2]


Reference:
[1]. Konta, T., Xu, Q., Furusu, A., et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J. Biol. Chem. 276(16), 12697-12701 (2001).
[2]. Yamauchi, T., Waki, H., Kamon, J., et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108(7), 1001-1013 (2001).