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O-7460
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-7460图片
CAS NO:1572051-31-0
规格:98%
分子量:478.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position.
CAS:1572051-31-0
分子式:C25H48FO5P
分子量:478.6
纯度:98%
存储:Store at -20°C

Background:

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s >10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis >10 µM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.