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PF-04634817
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04634817图片
CAS NO:1228111-63-4
规格:98%
分子量:511.58
包装与价格:
包装价格(元)
10mg电议
50mg电议
1mg电议
5mg电议

产品介绍
PF-0463481,可口服的 CCR2/5 双重拮抗剂,与玻璃体内治疗相比,具有良好的眼部安全性。PF-0463481 安全且耐受性良好,正在开发用于治疗糖尿病肾病。
CAS:1228111-63-4
分子式:C25H36F3N5O3
分子量:511.58
纯度:98%
存储:Store at -20°C

Background:

PF-0463481, an oral CCR2/5 dual antagonist, with a favorable ocular safety profile versus intravitreal therapies[1]. PF-0463481 is safe and well-tolerated and being developed for the treatment of diabetic nephropathy[2]. CCR2 CCR5




[1]. Gale JD, et al. A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2659-2669. [2]. Gale JD, et al. Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.