PROTACSirt2-bindingmoiety1是Sirtuin2(Sirt2)选择性的、强效抑制剂，其IC50值为2.4μM。可用于开发基于SirReals的PROTAC。
CAS：1862237-99-7
分子式：C21H20N4O2S2
分子量：424.54
纯度：98%
存储：Store at -20°C

Background:

PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2)[1].

[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.