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VCE-004,8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VCE-004,8图片
CAS NO:1818428-24-8
规格:98%
分子量:433.58
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
VCE-004.8 是一种半合成,多靶点大麻喹啉,具有有效抗炎活性,特异性 PPARγ 和 CB2 受体双重激动剂。VCE-004.8 可以抑制脯氨酰-羟化酶 (PHDs) 并激活HIF 通路。VCE-004.8 减弱脂肪生成并防止饮食诱导的肥胖。
CAS:1818428-24-8
分子式:C28H35NO3
分子量:433.58
纯度:98%
存储:Store at -20°C

Background:

VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity[1]. VCE-004.8 inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. VCE-004.8 attenuates adipogenesis and prevents diet-induced obesity[2]. PPARγ CB2



VCE-004.8 ( injection; 20 mg/kg/day; for 3 weeks) induces a significant reduction in body weight gain, total fat mass, adipocyte volume and plasma triglycerides levels in HFD mice. VCE-004.8 can also significantly ameliorate glucose tolerance, reduce leptin levels (a marker of adiposity) and increase adiponectin and incretins (GLP-1 and GIP) levels[1].


[1]. Navarrete C, et al. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. J Neuroinflammation. 2018 Mar 1;15(1):64. [2]. Palomares B, et al. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. Sci Rep. 2018 Oct 31;8(1):16092.