Taurodeoxychloic Acid (sodium hydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。Taurodeoxychloic Acid (sodium hydrate) 被用于多种研究，如原发性胆汁性肝硬化 (PBC)，胰岛素抵抗，淀粉样变性，囊性纤维化，胆汁淤积和肌萎缩侧索硬化症。
CAS：110026-03-4
分子式：C26H47NNaO7S+
分子量：540.71
纯度：98%
存储：Store at -20°C

Background:

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1]. Caspase-12

Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington’s disease[2].

[1]. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. [2]. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington’s disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.