GW284543 (UNC10225170) 是一个选择性的 MEK5 抑制剂。GW284543 (UNC10225170) 降低 pERK5,并下调内源性MYC 蛋白。
CAS:790186-68-4
分子式:C23H20N2O3
分子量:372.42
纯度:98%
存储:Store at -20°C
Background:
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 (UNC10225170) reduces pERK5, and decreases endogenous MYC protein[1].
MEK5
[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.