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17-DMAG HCl(Alvespimycin)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-DMAG HCl(Alvespimycin)图片
CAS NO:467214-21-7
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
17DMAG, NSC 707545
产品介绍

生物活性

17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物,与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。

靶点信息

HSP90 (Cell-free assay)
62 nM

化学数据

目录号A10011
作用机制Inhibitor (抑制剂)
M. Wt653.2
FormulaC32H48N4O8.HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.467214-21-7
Synonyms17DMAG, NSC 707545
SMILESCC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl

溶解度

In vitro (25°C)DMSO127 mg/mL (194.42 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM15.31 mL76.55 mL153.09 mL
0.5 mM3.06 mL15.31 mL30.62 mL
1 mM1.53 mL7.65 mL15.31 mL
5 mM0.31 mL1.53 mL3.06 mL

*The above data is based on the productmolecular weight 653.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.