生物活性
17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。
靶点信息
| HSP90 (Cell-free assay) | | | | |
| 62 nM | | | | |
化学数据
| 目录号 | A10011 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 653.2 |
| Formula | C32H48N4O8.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 467214-21-7 |
| Synonyms | 17DMAG, NSC 707545 |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl |
溶解度
| In vitro (25°C) | DMSO | 127 mg/mL (194.42 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 15.31 mL | 76.55 mL | 153.09 mL |
| 0.5 mM | 3.06 mL | 15.31 mL | 30.62 mL |
| 1 mM | 1.53 mL | 7.65 mL | 15.31 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.06 mL |
*The above data is based on the productmolecular weight 653.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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