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2-Methoxyestradiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-Methoxyestradiol图片
CAS NO:362-07-2
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
2-ME2
产品介绍

生物活性

2-Methoxyestradiol是一种凋亡,抗增殖和抗血管生成剂。通过两种途径诱导p53诱导的细胞凋亡:p38和NF-κB的激活;和激活JNK和AP-1导致Bcl-2磷酸化。

靶点信息

HIF-2α (Rat aortic smooth muscle A-10 cells)Microtubule Associated (Cell-free assay)HIF-1α (MDA-MB-231 cells)

化学数据

目录号A10012
M. Wt302.4
FormulaC19H26O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.362-07-2
Synonyms2-ME2
SMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3

溶解度

In vitro (25°C)DMSO55 mg/mL (181.87 mM)
WaterInsoluble
EthanolInsoluble
In vivo2%DMSO+30%PEG300+5%Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM33.07 mL165.34 mL330.69 mL
0.5 mM6.61 mL33.07 mL66.14 mL
1 mM3.31 mL16.53 mL33.07 mL
5 mM0.66 mL3.31 mL6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.