生物活性
4-Methylumbelliferone是透明质酸（HA）合成的选择性抑制剂，IC50为0.4 mM。被认为可通过消耗HA合成的常用底物UDP-葡萄糖醛酸来起抑制剂的作用。
靶点信息
化学数据
| 目录号 | A10015 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 176.2 |
| Formula | C10H8O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 90-33-5 |
| Synonyms | 4-MU |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)O |
溶解度
| In vitro | DMSO | 30 mg/mL (170.29 mM) |
| Water | Insoluble |
| Ethanol | 30 mg/mL (170.29 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 56.75 mL | 283.77 mL | 567.54 mL |
| 0.5 mM | 11.35 mL | 56.75 mL | 113.51 mL |
| 1 mM | 5.68 mL | 28.38 mL | 56.75 mL |
| 5 mM | 1.14 mL | 5.68 mL | 11.35 mL |
*The above data is based on the productmolecular weight 176.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com