生物活性
Abiraterone (CB-7598)是一种有效CYP17抑制剂,20裂合酶(CYP17A1)。
靶点信息
CYP17 (Cell-free assay) | | | | |
2 nM | | | | |
化学数据
目录号 | A10020 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 349.2 |
Formula | C24H31NO |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 154229-19-3 |
Synonyms | CB-7598, CB7598 |
SMILES | C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 28.64 mL | 143.18 mL | 286.37 mL |
0.5 mM | 5.73 mL | 28.64 mL | 57.27 mL |
1 mM | 2.86 mL | 14.32 mL | 28.64 mL |
5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
*The above data is based on the productmolecular weight 349.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.