生物活性
ABT-751 (E-7010)是一种抗有丝分裂剂,可抑制微管聚合,并在秋水仙碱位点与β-微管蛋白结合。在G2M期阻断细胞周期并诱导凋亡。
靶点信息
化学数据
目录号 | A10024 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 371.4 |
Formula | C18H17N3O4S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 141430-65-1 |
Synonyms | ABT751 |
SMILES | COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O |
溶解度
In vitro (25°C) | DMSO | 71 mg/mL (191.16 mM) |
Water | Insoluble |
Ethanol | 12 mg/mL (32.3 mM) |
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 14 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 26.93 mL | 134.63 mL | 269.25 mL |
0.5 mM | 5.39 mL | 26.93 mL | 53.85 mL |
1 mM | 2.69 mL | 13.46 mL | 26.93 mL |
5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.